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Wellness & Functional Medicine
GLP-1 Weight Loss Program preview article image

Additional Info

  • Consults are free!
  • Your initiation visit is $100 and includes lab review, medical clearance, program design, and prescribing.
  • On-site lab draws are available for added convenience.
  • All medication is compounded at a licensed pharmacy and customized for you (based on plan tier)
  • Physician-directed care with support from on-site medical staff
  • Priority support & ongoing dose guidance
  • Weekly check-ins, either virtually or on-site with injection administration
  • Monthly progress visit and dose adjustment (if needed)

🔬 Semaglutide vs. Tirzepatide vs. Retatrutide

All medications are powerful GLP-1 receptor agonists used in medically supervised weight loss programs—but they differ slightly in how they work, how effective they are, and how well they’re tolerated.

Feature Semaglutide Tirzepatide Retatrutide
Mechanism GLP-1 receptor agonist Dual GLP-1 + GIP receptor agonist Triple agonist — GLP-1 + GIP + glucagon receptors
How it works Slows gastric emptying, reduces appetite, improves insulin sensitivity Same as semaglutide, plus enhanced fat metabolism and insulin response due to GIP action All of the above, plus glucagon receptor activity that increases energy expenditure and enhances fat metabolism beyond GLP-1/GIP alone
Weight loss potential ~15% of body weight (avg) ~20%+ of body weight (avg) in trials ~24%+ of body weight (avg) in trials
Onset of results Gradual over 8–12 weeks Often faster appetite suppression Appetite suppression often within the first 1–2 weeks; rapid metabolic response
Tolerability Nausea and GI symptoms common early Similar, sometimes slightly more tolerable Similar GI profile to semaglutide and tirzepatide; gradual titration recommended
Dosing 0.22–2.3 mg weekly 2–13.5 mg weekly 1–12 mg weekly
Cost (compounded) Lower Middle Highest
Best for Mild to moderate weight loss or those preferring a gentler ramp-up Clients wanting faster results or with insulin resistance/metabolic syndrome Clients with higher weight loss goals, metabolic resistance, or those who have plateaued on semaglutide or tirzepatide